Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats
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چکیده
منابع مشابه
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats.
Hepatic steatosis is commonly present during the development of insulin resistance, and it is a clear sign of lipotoxicity attributable in part to an accelerated lipogenesis. There is evidence that a soy protein diet prevents the overexpression of hepatic sterol-regulatory element binding protein-1 (SREBP-1), decreasing lipid accumulation. Therefore, the aim of the present work was to study whe...
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Background: One in five adults in the United States is obese as defined by a body mass index of 30 kg/m 2 . Obesity is associated with metabolic syndrome, a combination of medical conditions including cardiovascular disease, type 2 diabetes, hypertension, hypercholesterolemia, and hypertriglyceridemia. These conditions present challenges to the medical care system and require a multifaceted app...
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متن کاملSoy protein affects serum insulin and hepatic SREBP-1 mRNA and reduces fatty liver in rats.
The consumption of soy protein was shown to reduce blood lipids in humans and other animal species. Furthermore, it was shown that the ingestion of soy protein maintains normal insulinemia. Thus, the purpose of the present study was to determine whether soy protein affects the synthesis of lipids in the liver through sterol-regulatory element binding protein-1 (SREBP-1) due to modulation of ins...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2005
ISSN: 0022-2275
DOI: 10.1194/jlr.m500067-jlr200